Serological endpoints:

Most tests performed in the TML rely on the visible agglutination of red blood cells as an end-point, interpreted as indicating the binding of antibodies to antigens on the red blood cell surface.

In rare instances, the hemolysis of red blood cells, indicating the activation of the complement cascade and formation of the membrane attack complex, is used as a test end-point.

Depending on what type of test is being performed, the antibodies and/or antigens used can be donor-derived, recipient-derived or provided as test reagents.

Next page: Serological endpoints: Agglutination - Stage 1

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